SF
| Pos | No | Player 1 | No | Player 2 | No | Player 3 | No | Player 4 | No | Player 5 |
|---|---|---|---|---|---|---|---|---|---|---|
| Offense | ||||||||||
| LWR | 19 | Samuel, Deebo 19/2 | 18 | Pettis, Dante 18/2 | 84 | Bourne, Kendrick CF17 | ||||
| RWR | 17 | SANDERS, EMMANUEL T/Den | 13 | James, Richie 18/7 | 81 | Matthews, Jordan SF19 | ||||
| LT | 74 | STALEY, JOE 07/1 | 67 | Skule, Justin 19/6 | ||||||
| LG | 75 | Tomlinson, Laken T/Det | 60 | Brunskill, Daniel SF19 | ||||||
| C | 63 | GARLAND, BEN U/Atl | ||||||||
| RG | 68 | PERSON, MIKE U/Ind | ||||||||
| RT | 69 | McGlinchey, Mike 18/1 | ||||||||
| TE | 85 | Kittle, George 17/5 | 82 | Dwelley, Ross CF18 | 83 | Toilolo, Levine U/Det | 43 | Helm, Daniel W/LAC | ||
| QB | 10 | Garoppolo, Jimmy T/NE | 4 | Mullens, Nick CF17 | 3 | Beathard, CJ 17/3 | ||||
| RB | 22 | Breida, Matt CF17 | 26 | Coleman, Tevin U/Atl | 31 | Mostert, Raheem SF16 | 30 | Wilson, Jeffery CF18 | ||
| FB | 44 | Juszczyk, Kyle U/Bal | ||||||||
| Defense | ||||||||||
| LDE | 55 | Ford, Dee T/KC | 97 | Bosa, Nick 19/1 | 92 | Valoaga, Jeremiah SF19 | ||||
| LDT | 96 | Day, Sheldon W/Jax | 77 | Taylor, Jullian 18/7 | ||||||
| RDT | 99 | Buckner, DeForest 16/1 | 95 | Street, Kentavius 18/4 | ||||||
| RDE | 91 | Armstead, Arik 15/1 | 94 | Thomas, Solomon 17/1 | ||||||
| SAM | 51 | Al-Shaair, Azeez CF19 | 53 | Nzeocha, Mark P/Dal | ||||||
| MIKE | 54 | Warner, Fred 18/3 | ||||||||
| WILL | 57 | Greenlaw, Dre 19/5 | 47 | Lee, Elijah P/Min | ||||||
| LCB | 25 | SHERMAN, RICHARD CC/Sea | 38 | Exum, Antone SF17 | ||||||
| SS | 29 | Tartt, Jaquiski 15/2 | 36 | Harris, Marcell 18/6 | ||||||
| FS | 20 | Ward, Jimmie 14/1 | 33 | Moore, Tarvarius 18/3 | 38 | Johnson, Dontae 14/4 | ||||
| RCB | 23 | Witherspoon, Ahkello 17/3 | 41 | Moseley, Emmanuel CF18 | ||||||
| NB | 24 | Williams, K'Waun SF17 | 32 | Reed, DJ 18/5 | ||||||
| Special Teams | ||||||||||
| PT | 6 | Wishnowsky, Mitch 19/4 | ||||||||
| PK | 9 | GOULD, ROBBIE U/NYG | ||||||||
| LS | 86 | NELSON, KYLE SF14 | ||||||||
| H | 6 | Wishnowsky, Mitch 19/4 | ||||||||
| KO | 9 | GOULD, ROBBIE U/NYG | ||||||||
| PR | 13 | James, Richie 18/7 | 18 | Pettis, Dante 18/2 | 32 | Reed, DJ 18/5 | ||||
| KR | 13 | James, Richie 18/7 | 32 | Reed, DJ 18/5 | 22 | Breida, Matt CF17 | ||||
| Practice Squad | ||||||||||
| PS | 71 | Jones-Smith, Jaryd OT | 90 | Givens, Kevin DT | 40 | Tabor, Jalen CB | 00 | Thieneman, Jacob SS | 50 | Alfieri, Joey OB |
| PS | 81 | Thompson, Chris WR | 76 | Reynolds, Ross OG | 64 | Barrett, Alex DE | 65 | Amichia, Kofi OC | 48 | Kelly, Jermaine CB |
| Reserves | ||||||||||
| RES | 78 | Coleman, Shon IR | 1 | Poindexter, Shawn IR | 35 | Harris, Tim IR | 56 | Alexander, Kwon IR | 28 | McKinnon, Jerick IR |
| RES | 64 | Lauderdale, Andrew IR | 88 | CELEK, GARRETT IR | 15 | Taylor, Trent IR | 59 | CONDO, JON IR | 17 | Hurd, Jalen IR |
| RES | 27 | Verrett, Jason IR | 98 | Blair, Ronald IR | 90 | Moore, Damontre IR | 11 | Goodwin, Marquise IR | 45 | Flannigan-Fowles, Demetrius PS/INJ |
| RES | 58 | Richburg, Weston IR | 93 | Jones, DJ IR | ||||||