SF
| Pos | No | Player 1 | No | Player 2 | No | Player 3 | No | Player 4 | No | Player 5 |
|---|---|---|---|---|---|---|---|---|---|---|
| Offense | ||||||||||
| LWR | 19 | Samuel, Deebo 19/2 | 84 | Bourne, Kendrick CF17 | 18 | Pettis, Dante 18/2 | 89 | Thompson, Chris SF19 | 1 | Poindexter, Shawn CF19 |
| RWR | 14 | Hurd, Jalen 19/3 | 11 | Goodwin, Marquise U/Buf | 13 | James, Richie 18/7 | 15 | Taylor, Trent 17/5 | 00 | BENJAMIN, TRAVIS U/LAC |
| LT | 74 | STALEY, JOE 07/1 | 67 | Skule, Justin 19/6 | 78 | Coleman, Shon T/Cle | ||||
| LG | 75 | Tomlinson, Laken T/Det | 65 | Amichia, Kofi SF19 | ||||||
| C | 58 | Richburg, Weston U/NYG | 63 | GARLAND, BEN U/Atl | 00 | Brendel, Jake SF20 | ||||
| RG | 00 | COMPTON, TOM U/NYJ | 76 | Reynolds, Ross CF19 | ||||||
| RT | 69 | McGlinchey, Mike 18/1 | 60 | Brunskill, Daniel SF19 | 71 | Jones-Smith, Jaryd SF19 | 00 | Wester, Leonard SF20 | ||
| TE | 85 | Kittle, George 17/5 | 82 | Dwelley, Ross CF18 | 43 | Helm, Daniel W/LAC | ||||
| QB | 10 | Garoppolo, Jimmy T/NE | 4 | Mullens, Nick CF17 | 3 | Beathard, CJ 17/3 | ||||
| RB | 31 | Mostert, Raheem SF16 | 22 | Breida, Matt CF17 | 26 | Coleman, Tevin U/Atl | 30 | Wilson, Jeffery CF18 | 28 | McKinnon, Jerick U/Min |
| FB | 44 | Juszczyk, Kyle U/Bal | ||||||||
| Defense | ||||||||||
| LDE | 91 | Armstead, Arik 15/1 | 55 | Ford, Dee T/KC | 98 | Blair, Ronald 16/5 | 00 | Kongbo, Jonathan SF20 | ||
| LDT | 94 | Thomas, Solomon 17/1 | 77 | Taylor, Jullian 18/7 | 00 | Henry, Willie SF20 | ||||
| RDT | 93 | Jones, DJ 17/6 | 90 | Givens, Kevin CF19 | 66 | Smith, Ray CF19 | ||||
| RDE | 97 | Bosa, Nick 19/1 | 95 | Street, Kentavius 18/4 | 64 | Barrett, Alex SF19 | 00 | Hyder, Kerry U/Dal | ||
| SAM | 56 | Alexander, Kwon U/TB | 53 | NZEOCHA, MARK P/Dal | ||||||
| MIKE | 54 | Warner, Fred 18/3 | 00 | Walker, Joe U/Arz | 51 | Al-Shaair, Azeez CF19 | ||||
| WILL | 57 | Greenlaw, Dre 19/5 | 50 | Alfieri, Joey CF19 | ||||||
| LCB | 25 | SHERMAN, RICHARD CC/Sea | 40 | Tabor, Jalen SF19 | 35 | Harris, Tim 19/6 | ||||
| SS | 29 | Tartt, Jaquiski 15/2 | 36 | Harris, Marcell 18/6 | 00 | Thieneman, Jacob CF19 | 45 | FLANNIGAN-FOWLES, DEMETRIUS CF19 | 00 | Edwards, Chris SF20 |
| FS | 20 | Ward, Jimmie 14/1 | 33 | Moore, Tarvarius 18/3 | 00 | Kindred, Derrick SF20 | ||||
| RCB | 23 | Witherspoon, Ahkello 17/3 | 41 | Moseley, Emmanuel CF18 | 48 | Kelly, Jermaine SF19 | ||||
| NB | 24 | Williams, K'Waun SF17 | 32 | Reed, DJ 18/5 | ||||||
| Special Teams | ||||||||||
| PT | 6 | Wishnowsky, Mitch 19/4 | ||||||||
| PK | 9 | GOULD, ROBBIE U/NYG | ||||||||
| LS | 86 | NELSON, KYLE SF14 | ||||||||
| H | 6 | Wishnowsky, Mitch 19/4 | ||||||||
| KO | 9 | GOULD, ROBBIE U/NYG | ||||||||
| PR | 13 | James, Richie 18/7 | 18 | Pettis, Dante 18/2 | 32 | Reed, DJ 18/5 | ||||
| KR | 13 | James, Richie 18/7 | 32 | Reed, DJ 18/5 | 22 | Breida, Matt CF17 | ||||
| Reserves | ||||||||||
| RET | 88 | CELEK, GARRETT RET | 59 | CONDO, JON RET | ||||||
| Free Agents / Cap Casualties | ||||||||||
| FACC | 35 | Johnson, Dontae UFA | 81 | Matthews, Jordan UFA | 93 | MITCHELL, EARL UFA | 90 | Moore, Damontre UFA | 27 | Verrett, Jason UFA |
| FACC | 64 | Lauderdale, Andrew RFA | ||||||||