SD
| Pos | No. | Player 1 | No | Player 2 | No | Player 3 | No | Player 4 | No | Player 5 |
|---|---|---|---|---|---|---|---|---|---|---|
| Offense | ||||||||||
| OFF | ||||||||||
| LWR | 81 | Williams, Mike 17/1 | ||||||||
| RWR | 5 | Palmer, Joshua 21/3 | 11 | Moore Jr., Jason CF19 | ||||||
| SWR | 13 | ALLEN, KEENAN 13/3 | 1 | Carter, DeAndre U/Was | ||||||
| LT | 68 | Salyer, Jamaree 22/6 | 74 | Norton, Storm SF20 | ||||||
| LG | 71 | FEILER, MATT U/Pit | ||||||||
| C | 63 | LINSLEY, COREY U/GB | 76 | Clapp, Will SF22 | ||||||
| RG | 77 | Johnson, Zion 22/1 | 64 | Jaimes, Brenden 21/5 | ||||||
| RT | 79 | Pipkins III, Trey 19/3 | ||||||||
| TE | 7 | Everett, Gerald U/Sea | 89 | Parham Jr., Donald SF20 | 88 | McKitty, Tre' 21/3 | 82 | RODGERS, RICHARD SF22 | ||
| QB | 10 | Herbert, Justin 20/1 | 4 | DANIEL, CHASE CC/Det | 2 | Stick, Easton 19/5 | ||||
| RB | 30 | Ekeler, Austin CF17 | 25 | Kelley, Joshua 20/4 | 20 | Michel, Sony SF22 | 28 | Spiller, Isaiah 22/4 | ||
| FB | 40 | Horvath, Zander 22/7 | ||||||||
| Defense | ||||||||||
| DEF | ||||||||||
| DE | 56 | Fox, Morgan CC/Car | 99 | Tillery, Jerry 19/1 | ||||||
| NT | 69 | Joseph-Day, Sebastian U/LAR | 93 | Ogbonnia, Otito 22/5 | ||||||
| DT | 98 | Johnson, Austin U/NYG | 95 | Covington, Christian U/Cin | ||||||
| OLB | 8 | VAN NOY, KYLE CC/NE | 59 | Tuszka, Derrek W/Ten | ||||||
| ILB | 9 | Murray Jr., Kenneth 20/1 | 42 | Reeder, Troy U/LAR | 57 | Ogbongbemiga, Amen CF21 | ||||
| ILB | 49 | Tranquill, Drue 19/4 | 31 | Niemann, Nick 21/6 | ||||||
| OLB | 52 | MACK, KHALIL T/CHI | 94 | Rumph II, Chris 21/4 | ||||||
| LCB | 27 | Jackson, J.C. U/NE | 43 | Davis, Michael CF17 | ||||||
| SS | 3 | James Jr., Derwin 18/1 | 32 | Gilman, Alohi 20/6 | ||||||
| FS | 24 | Adderley, Nasir 19/2 | 22 | Woods, JT 22/3 | ||||||
| RCB | 26 | Samuel Jr., Asante 21/2 | 33 | Leonard, Deane 22/7 | ||||||
| NB | 23 | CALLAHAN, BRYCE U/Den | 36 | Taylor, Ja'Sir 22/6 | ||||||
| Special Teams | ||||||||||
| ST | ||||||||||
| PT | 16 | Scott, JK U/Jax | ||||||||
| PK | 6 | HOPKINS, DUSTIN SF21 | ||||||||
| LS | 47 | HARRIS, JOSH U/Atl | ||||||||
| H | 16 | Scott, JK U/Jax | ||||||||
| KO | 6 | HOPKINS, DUSTIN SF21 | ||||||||
| PR | 1 | Carter, DeAndre U/Was | ||||||||
| KR | 1 | Carter, DeAndre U/Was | 25 | Kelley, Joshua 20/4 | ||||||
| Practice Squad | ||||||||||
| PS | ||||||||||
| PS | 34 | Rountree III, Larry RB | 92 | Gaziano, Joe DE | 83 | Bandy, Michael WR | 78 | Bailey, Zack OT | 80 | Reed, Joe WR |
| PS | 58 | Maddox-Williams, Tyreek ILB | 87 | Kampmoyer, Hunter TE | 29 | Webb Jr., Mark S | 41 | Layne, Raheem S | 54 | Kemp, Carlo DE |
| PS | 96 | Fehoko, Breiden DT | 39 | Jacquet, Michael CB | 84 | Hightower, John WR | 73 | Sarell, Foster OT | 37 | Hall, Kemon CB |
| Reserves | ||||||||||
| RES | ||||||||||
| RES | 62 | Trainer, Andrew IR | 91 | Merrill, Forrest IR | 60 | Weaver, Isaac IR | 53 | Lloyd, Damon IR | 48 | Smartt, Stone NFI |
| RES | 70 | Slater, Rashawn IR-4 | 15 | Guyton, Jalen IR-4 | 97 | Bosa, Joey IR-4 | ||||